Invitrogen
LGR5 is a G-protein coupled receptor that has no known endogenous ligands. The receptor is a target for the Wnt signalling pathway. Increased expression of LGR5 has been linked to ovarian, colon and hepatocellular cancers. Anti-LGR5 antibody is specific for LGR5 in humans. Physical form. LGR5 antibody LS-A1236 is an unconjugated rabbit polyclonal antibody to human LGR5 (GPR49). Validated for IF and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 3 publications.
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
antibody
LGR5 Monoclonal Antibody (OTI2A2)
MA5-25644
100µl
381 USD
monoclonal
mouse
nonconjugated
![Immunofluorescence Immunofluorescence](https://assets.thermofisher.com/TFS-Assets/gallery/MA5-25644-LGR5-ICC-IF-2-20171219150641.jpg)
OTI2A2
human, mouse
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
Antibody
LGR5 Monoclonal Antibody (OTI2A2)
MA5-25644
MA525644
100µl
381 USD
Monoclonal
Affinity Chromatography
Mouse
Human, Mouse
Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry (Paraffin): 1:150, Immunoprecipitation: 4 µg/mL, Western Blot: 1:2000
Human, Mouse
OTI2A2
IgG1
-20° C, Avoid Freeze/Thaw Cycles
G protein-coupled receptor GPR49 has been reported to be expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries and from human germ cell, uterus, and brain libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This ''turn-off'' activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
Human recombinant protein fragment corresponding to amino acids 250-550 of LGR5 produced in HEK293T cell
Liquid
Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunofluorescence: 1:100, Immunohistochemistry (Paraffin): 1:150, Immunoprecipitation: 4 µg/mL, Western Blot: 1:2000
FEX; GPR49; GPR67; GRP49; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; leucine-rich repeat-containing G protein-coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5; orphan G protein-coupled receptor HG38
Thermo Fisher Scientific
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